NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2(V617F)-positive myeloproliferative neoplasm cells

Recent data indicate that IGF1R/IRS signaling is a potential therapeutic target in BCR-ABL1-negative myeloproliferative neoplasms (MPN); in this pathway, IRS2 is involved in the malignant transformation induced by JAK2(V617F), and upregulation of IGF1R signaling induces the MPN phenotype. NT157, a s...

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Publicado no:Signal Transduct Target Ther
Main Authors: Fenerich, Bruna Alves, Fernandes, Jaqueline Cristina, Rodrigues Alves, Ana Paula Nunes, Coelho-Silva, Juan Luiz, Scopim-Ribeiro, Renata, Scheucher, Priscila Santos, Eide, Christopher A., Tognon, Cristina E., Druker, Brian J., Rego, Eduardo Magalhães, Machado-Neto, João Agostinho, Traina, Fabiola
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978524/
https://ncbi.nlm.nih.gov/pubmed/32296029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-019-0102-5
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