Reversine exhibits antineoplastic activity in JAK2(V617F)-positive myeloproliferative neoplasms

JAK2/STAT signaling participates in the Ph-negative myeloproliferative neoplasms (MPN) pathophysiology and has been targeted by ruxolitinib, a JAK1/2 inhibitor. In the present study, the impact of ruxolitinib treatment on cytoskeleton-related genes expression was explored. In SET2 cells, AURKA and A...

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Опубликовано в: :Sci Rep
Главные авторы: Lima, Keli, Carlos, Jorge Antonio Elias Godoy, Alves-Paiva, Raquel de Melo, Vicari, Hugo Passos, Souza Santos, Fábio Pires de, Hamerschlak, Nelson, Costa-Lotufo, Leticia Veras, Traina, Fabiola, Machado-Neto, João Agostinho
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6616334/
https://ncbi.nlm.nih.gov/pubmed/31289316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46163-2
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