Corticosterone induces neurotoxicity in PC12 cells via disrupting autophagy flux mediated by AMPK/mTOR signaling

AIMS: Our previous study indicated that chronic stress caused autophagy impairment and subsequent neuron apoptosis in hippocampus. However, the mechanism underlying the stress‐induced damage to neurons is unclear. In present work, we investigated whether stress‐level glucocorticoids (GCs) GCs promot...

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Publicat a:CNS Neurosci Ther
Autors principals: Ma, Run‐Dong, Zhou, Gui‐Juan, Qu, Miao, Yi, Ji‐Hong, Tang, Ya‐Ling, Yang, Xiang‐Yi, Nie, Ya‐Xiong, Gu, Hong‐Feng
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978254/
https://ncbi.nlm.nih.gov/pubmed/31423743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.13212
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