Corticosterone induces neurotoxicity in PC12 cells via disrupting autophagy flux mediated by AMPK/mTOR signaling

AIMS: Our previous study indicated that chronic stress caused autophagy impairment and subsequent neuron apoptosis in hippocampus. However, the mechanism underlying the stress‐induced damage to neurons is unclear. In present work, we investigated whether stress‐level glucocorticoids (GCs) GCs promot...

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Vydáno v:CNS Neurosci Ther
Hlavní autoři: Ma, Run‐Dong, Zhou, Gui‐Juan, Qu, Miao, Yi, Ji‐Hong, Tang, Ya‐Ling, Yang, Xiang‐Yi, Nie, Ya‐Xiong, Gu, Hong‐Feng
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978254/
https://ncbi.nlm.nih.gov/pubmed/31423743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.13212
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