Corticosterone induces neurotoxicity in PC12 cells via disrupting autophagy flux mediated by AMPK/mTOR signaling

AIMS: Our previous study indicated that chronic stress caused autophagy impairment and subsequent neuron apoptosis in hippocampus. However, the mechanism underlying the stress‐induced damage to neurons is unclear. In present work, we investigated whether stress‐level glucocorticoids (GCs) GCs promot...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:CNS Neurosci Ther
Prif Awduron: Ma, Run‐Dong, Zhou, Gui‐Juan, Qu, Miao, Yi, Ji‐Hong, Tang, Ya‐Ling, Yang, Xiang‐Yi, Nie, Ya‐Xiong, Gu, Hong‐Feng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978254/
https://ncbi.nlm.nih.gov/pubmed/31423743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.13212
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