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Ganaxolone enhances microglial clearance activity and promotes remyelination in focal demyelination in the corpus callosum of ovariectomized rats

AIM: Experimental studies have shown that the progesterone metabolite, allopregnanolone, is endowed with promyelinating effects. The mechanisms underlying these promyelinating effects are not well understood. Therefore, we explored the impact of allopregnanolone's synthetic analogue, ganaxolone...

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Bibliografiske detaljer
Udgivet i:CNS Neurosci Ther
Main Authors: Mouihate, Abdeslam, Kalakh, Samah
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978248/
https://ncbi.nlm.nih.gov/pubmed/31332963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.13195
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