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Ganaxolone enhances microglial clearance activity and promotes remyelination in focal demyelination in the corpus callosum of ovariectomized rats

AIM: Experimental studies have shown that the progesterone metabolite, allopregnanolone, is endowed with promyelinating effects. The mechanisms underlying these promyelinating effects are not well understood. Therefore, we explored the impact of allopregnanolone's synthetic analogue, ganaxolone...

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Publicat a:CNS Neurosci Ther
Autors principals: Mouihate, Abdeslam, Kalakh, Samah
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978248/
https://ncbi.nlm.nih.gov/pubmed/31332963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.13195
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