Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2α/ATF4/CHOP Signaling Pathway

Apoptosis induced by endoplasmic reticulum (ER) stress plays a crucial role in mediating brain damage after ischemic stroke. Recently, Hes1 (hairy and enhancer of split 1) has been implicated in the regulation of ER stress, but whether it plays a functional role after ischemic stroke and the underly...

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Publicat a:Neurosci Bull
Autors principals: Li, Yueyong, Zhang, Yingjun, Fu, Huangde, Huang, Huadong, Lu, Qifeng, Qin, Houji, Wu, Yingning, Huang, Huatuo, Mao, Guizhen, Wei, Zhongheng, Liao, Pinhu
Format: Artigo
Idioma:Inglês
Publicat: Springer Singapore 2019
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6977800/
https://ncbi.nlm.nih.gov/pubmed/31309426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-019-00411-7
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