Bypassing Phase Variation of Lipooligosaccharide (LOS): Using Heptose 1 Glycan Mutants To Establish Widespread Efficacy of Gonococcal Anti-LOS Monoclonal Antibody 2C7

The sialylatable lacto-N-neotetraose (LNnT; Gal-GlcNAc-Gal-Glc) moiety from heptose I (HepI) of the lipooligosaccharide (LOS) of Neisseria gonorrhoeae undergoes positive selection during human infection. Lactose (Gal-Glc) from HepII, although phase variable, is commonly expressed in humans; loss of...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Infect Immun
Hlavní autoři: Chakraborti, Srinjoy, Gulati, Sunita, Zheng, Bo, Beurskens, Frank J., Schuurman, Janine, Rice, Peter A., Ram, Sanjay
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Bacterial Infections
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6977115/
https://ncbi.nlm.nih.gov/pubmed/31818965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00862-19
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky