Phase-variable heptose I glycan extensions modulate efficacy of 2C7 vaccine antibody directed against Neisseria gonorrhoeae lipooligosaccharide

Neisseria gonorrhoeae , the causative agent of the sexually transmitted infection, gonorrhea, has developed resistance to most conventional antibiotics. Safe and effective vaccines against gonorrhea are needed urgently. A candidate vaccine that targets a lipooligosaccharide (LOS) epitope recognized...

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Veröffentlicht in:J Immunol
Hauptverfasser: Chakraborti, Srinjoy, Lewis, Lisa A., Cox, Andrew D., St Michael, Frank, Li, Jianjun, Rice, Peter A., Ram, Sanjay
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875794/
https://ncbi.nlm.nih.gov/pubmed/27183633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600374
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