A Novel Sialylation Site on Neisseria gonorrhoeae Lipooligosaccharide Links Heptose II Lactose Expression with Pathogenicity

Sialylation of lacto-N-neotetraose (LNnT) extending from heptose I (HepI) of gonococcal lipooligosaccharide (LOS) contributes to pathogenesis. Previously, gonococcal LOS sialyltransterase (Lst) was shown to sialylate LOS in Triton X-100 extracts of strain 15253, which expresses lactose from both Hep...

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Bibliografiska uppgifter
I publikationen:Infect Immun
Huvudupphovsmän: Ram, Sanjay, Gulati, Sunita, Lewis, Lisa A., Chakraborti, Srinjoy, Zheng, Bo, DeOliveira, Rosane B., Reed, George W., Cox, Andrew D., Li, Jianjun, St. Michael, Frank, Stupak, Jacek, Su, Xiao-Hong, Saha, Sudeshna, Landig, Corinna S., Varki, Ajit, Rice, Peter A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2018
Ämnen:
Molecular Pathogenesis
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056883/
https://ncbi.nlm.nih.gov/pubmed/29844237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00285-18
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