Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity

Apparent permeability coefficients (P(app)) across a human intestinal epithelial Caco-2 cell monolayer were measured for a range of industrial/drug chemicals. A predictive equation for determining in vitro P(app) values of fifty-six substances was set up using multivariate regression analysis based...

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Detalhes bibliográficos
Publicado no:Toxicol Rep
Main Authors: Kamiya, Yusuke, Takaku, Hiroka, Yamada, Rio, Akase, Chisato, Abe, Yuto, Sekiguchi, Yuko, Murayama, Norie, Shimizu, Makiko, Kitajima, Masato, Shono, Fumiaki, Funatsu, Kimito, Yamazaki, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6976901/
https://ncbi.nlm.nih.gov/pubmed/31993333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2020.01.004
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