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Extrapolation of Hepatic Concentrations of Industrial Chemicals Using Pharmacokinetic Models to Predict Hepatotoxicity
In this review, we describe the absorption rates (Caco-2 cell permeability) and hepatic/plasma pharmacokinetics of 53 diverse chemicals estimated by modeling virtual oral administration in rats. To ensure that a broad range of chemical structures is present among the selected substances, the propert...
Guardat en:
| Publicat a: | Toxicol Res |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Korean Society of Toxicology
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6791659/ https://ncbi.nlm.nih.gov/pubmed/31636840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5487/TR.2019.35.4.295 |
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