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G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody

The experimental evidence that Adhesion G Protein-Coupled Receptors (aGPCRs) functionally couple to heterotrimeric G proteins has been emerging in incremental steps, but attributing biological significance to their G protein signalling function still presents a major challenge. Here, utilising activ...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Bhudia, Nisha, Desai, Sapna, King, Natalie, Ancellin, Nicolas, Grillot, Didier, Barnes, Ashley A., Dowell, Simon J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6976652/
https://ncbi.nlm.nih.gov/pubmed/31969668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57989-6
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