Activation of Adhesion GPCR EMR2/ADGRE2 Induces Macrophage Differentiation and Inflammatory Responses via Gα(16)/Akt/MAPK/NF-κB Signaling Pathways

EMR2/ADGRE2 is a human myeloid-restricted adhesion G protein-coupled receptor critically implicated in vibratory urticaria, a rare type of allergy caused by vibration-induced mast cell activation. In addition, EMR2 is also highly expressed by monocyte/macrophages and has been linked to neutrophil mi...

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Vydáno v:Front Immunol
Hlavní autoři: I, Kuan-Yu, Huang, Yi-Shu, Hu, Ching-Hsun, Tseng, Wen-Yi, Cheng, Chia-Hsin, Stacey, Martin, Gordon, Siamon, Chang, Gin-Wen, Lin, Hsi-Hsien
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376562/
https://ncbi.nlm.nih.gov/pubmed/28421075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00373
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