A Pilot Study of Sirolimus in Subjects with Cowden Syndrome or Other Syndromes Characterized by Germline Mutations in PTEN

LESSONS LEARNED. This is the first human interventional study in patients with Cowden syndrome that is driven by inactivation of germline PTEN gene. Single‐agent sirolimus, a mTOR inhibitor, suppressed mTOR signaling in surrogate human tissues without significant toxicity. BACKGROUND. Cowden syndrom...

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Detalhes bibliográficos
Publicado no:Oncologist
Main Authors: Komiya, Takefumi, Blumenthal, Gideon M., DeChowdhury, Roopa, Fioravanti, Susan, Ballas, Marc S., Morris, John, Hornyak, Thomas J., Wank, Stephen, Hewitt, Stephen M., Morrow, Betsy, Memmott, Regan M., Rajan, Arun, Dennis, Phillip A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Clinical Trial Results
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975943/
https://ncbi.nlm.nih.gov/pubmed/31350329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2019-0514
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