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A Pilot Study of Sirolimus in Subjects with Cowden Syndrome or Other Syndromes Characterized by Germline Mutations in PTEN
LESSONS LEARNED. This is the first human interventional study in patients with Cowden syndrome that is driven by inactivation of germline PTEN gene. Single‐agent sirolimus, a mTOR inhibitor, suppressed mTOR signaling in surrogate human tissues without significant toxicity. BACKGROUND. Cowden syndrom...
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| 出版年: | Oncologist |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley & Sons, Inc.
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6975943/ https://ncbi.nlm.nih.gov/pubmed/31350329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2019-0514 |
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