Chemotherapy Toxicity in BRCA Mutation Carriers Undergoing First‐Line Platinum‐Based Chemotherapy

OBJECTIVE. BRCA mutations are the most frequent mutations causing homologous recombination defects in epithelial ovarian cancers (EOC). Germline mutation carriers are heterozygous for the mutation and harbor one defective allele in all cells. This has been hypothesized to cause increased susceptibil...

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Bibliographic Details
Published in:Oncologist
Main Authors: Weitzner, Omar, Yagur, Yael, Kadan, Yfat, Beiner, Mario E., Fishman, Ami, Ben Ezry, Emilie, Amitai Komem, Daphna, Helpman, Limor
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Inc. 2019
Subjects:
Gynecologic Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975939/
https://ncbi.nlm.nih.gov/pubmed/31346131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2019-0272
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