Chemotherapy Toxicity in BRCA Mutation Carriers Undergoing First‐Line Platinum‐Based Chemotherapy

OBJECTIVE. BRCA mutations are the most frequent mutations causing homologous recombination defects in epithelial ovarian cancers (EOC). Germline mutation carriers are heterozygous for the mutation and harbor one defective allele in all cells. This has been hypothesized to cause increased susceptibil...

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Vydáno v:Oncologist
Hlavní autoři: Weitzner, Omar, Yagur, Yael, Kadan, Yfat, Beiner, Mario E., Fishman, Ami, Ben Ezry, Emilie, Amitai Komem, Daphna, Helpman, Limor
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2019
Témata:
Gynecologic Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975939/
https://ncbi.nlm.nih.gov/pubmed/31346131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2019-0272
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