Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis

Accumulation of senescent cells is associated with the progression of pulmonary fibrosis, but mechanisms accounting for this linkage are not well understood. To explore this issue, we investigated whether a class of biologically active profibrotic lipids, the leukotrienes (LT), is part of the senesc...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Wiley, Christopher D., Brumwell, Alexis N., Davis, Sonnet S., Jackson, Julia R., Valdovinos, Alexis, Calhoun, Cheresa, Alimirah, Fatouma, Castellanos, Carlos A., Ruan, Richard, Wei, Ying, Chapman, Harold A., Ramanathan, Arvind, Campisi, Judith, Jourdan Le Saux, Claude
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975274/
https://ncbi.nlm.nih.gov/pubmed/31687975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130056
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