Cellular senescence promotes skin carcinogenesis through p38MAPK and p44/p42 MAPK signaling

Cellular senescence entails an irreversible growth arrest that evolved in part to prevent cancer. Paradoxically, senescent cells secrete pro-inflammatory and growth-stimulatory molecules, termed the senescence-associated secretory phenotype (SASP), which is correlated with cancer cell proliferation...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Alimirah, Fatouma, Pulido, Tanya, Valdovinos, Alexis, Alptekin, Sena, Chang, Emily, Jones, Elijah, Diaz, Diego A., Flores, Jose, Velarde, Michael C., Demaria, Marco, Davalos, Albert R., Wiley, Christopher D., Limbad, Chandani, Desprez, Pierre-Yves, Campisi, Judith
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484313/
https://ncbi.nlm.nih.gov/pubmed/32641409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0108
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