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CTGF Is Increased in Basal Deposits and Regulates Matrix Production through the ERK (p42/p44(mapk)) MAPK and the p38 MAPK Signaling Pathways

PURPOSE: Matrix expansion is an early change in age-related maculopathy. The aim of this study was to determine whether connective tissue growth factor (CTGF) regulates the production of extracellular matrix components by retinal pigmented epithelial (RPE) cells. METHODS: ARPE-19 cells were treated...

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Main Authors: Nagai, Norihiro, Klimava, Alena, Lee, Wen-Hsiang, Izumi-Nagai, Kanako, Handa, James T.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729056/
https://ncbi.nlm.nih.gov/pubmed/19011018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.08-2383
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