The Machado–Joseph disease deubiquitylase ataxin‐3 interacts with LC3C/GABARAP and promotes autophagy

The pathology of spinocerebellar ataxia type 3, also known as Machado‐Joseph disease, is triggered by aggregation of toxic ataxin‐3 (ATXN3) variants containing expanded polyglutamine repeats. The physiological role of this deubiquitylase, however, remains largely unclear. Our recent work showed that...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Herzog, Laura K., Kevei, Éva, Marchante, Ricardo, Böttcher, Claudia, Bindesbøll, Christian, Lystad, Alf Håkon, Pfeiffer, Annika, Gierisch, Maria E., Salomons, Florian A., Simonsen, Anne, Hoppe, Thorsten, Dantuma, Nico P.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974715/
https://ncbi.nlm.nih.gov/pubmed/31625269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13051
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