Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease

Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We identified citalopram, a selective seroto...

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Veröffentlicht in:Brain
Hauptverfasser: Teixeira-Castro, Andreia, Jalles, Ana, Esteves, Sofia, Kang, Soosung, da Silva Santos, Liliana, Silva-Fernandes, Anabela, Neto, Mário F., Brielmann, Renée M., Bessa, Carlos, Duarte-Silva, Sara, Miranda, Adriana, Oliveira, Stéphanie, Neves-Carvalho, Andreia, Bessa, João, Summavielle, Teresa, Silverman, Richard B., Oliveira, Pedro, Morimoto, Richard I., Maciel, Patrícia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731417/
https://ncbi.nlm.nih.gov/pubmed/26373603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv262
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