Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease

Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We identified citalopram, a selective seroto...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Brain
Main Authors: Teixeira-Castro, Andreia, Jalles, Ana, Esteves, Sofia, Kang, Soosung, da Silva Santos, Liliana, Silva-Fernandes, Anabela, Neto, Mário F., Brielmann, Renée M., Bessa, Carlos, Duarte-Silva, Sara, Miranda, Adriana, Oliveira, Stéphanie, Neves-Carvalho, Andreia, Bessa, João, Summavielle, Teresa, Silverman, Richard B., Oliveira, Pedro, Morimoto, Richard I., Maciel, Patrícia
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731417/
https://ncbi.nlm.nih.gov/pubmed/26373603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv262
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados