Chronic Treatment with 17-DMAG Improves Balance and Coordination in A New Mouse Model of Machado-Joseph Disease

Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disease currently with no treatment. We describe a novel mouse model of MJD which expresses mutant human ataxin-3 at near endogenous levels and manifests MJD-like motor symptoms that appear gradually and prog...

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Autors principals: Silva-Fernandes, Anabela, Duarte-Silva, Sara, Neves-Carvalho, Andreia, Amorim, Marina, Soares-Cunha, Carina, Oliveira, Pedro, Thirstrup, Kenneth, Teixeira-Castro, Andreia, Maciel, Patrícia
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3996110/
https://ncbi.nlm.nih.gov/pubmed/24477711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-013-0255-9
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