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Citalopram reduces aggregation of ATXN3 in a YAC transgenic mouse model of Machado-Joseph disease

Machado-Joseph disease, also known as Spinocerebellar ataxia type 3, is a fatal polyglutamine disease with no disease-modifying treatment. The selective serotonin reuptake inhibitor citalopram was shown in nematode and mouse models to be a compelling repurposing candidate for Machado-Joseph disease...

詳細記述

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書誌詳細
出版年:Mol Neurobiol
主要な著者: Ashraf, Naila S., Duarte-Silva, Sara, Shaw, Emily D., Maciel, Patrícia, Paulson, Henry L., Teixeira-Castro, Andreia, Costa, Maria do Carmo
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417975/
https://ncbi.nlm.nih.gov/pubmed/30187384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1331-2
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