The Machado–Joseph disease deubiquitylase ataxin‐3 interacts with LC3C/GABARAP and promotes autophagy

The pathology of spinocerebellar ataxia type 3, also known as Machado‐Joseph disease, is triggered by aggregation of toxic ataxin‐3 (ATXN3) variants containing expanded polyglutamine repeats. The physiological role of this deubiquitylase, however, remains largely unclear. Our recent work showed that...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Herzog, Laura K., Kevei, Éva, Marchante, Ricardo, Böttcher, Claudia, Bindesbøll, Christian, Lystad, Alf Håkon, Pfeiffer, Annika, Gierisch, Maria E., Salomons, Florian A., Simonsen, Anne, Hoppe, Thorsten, Dantuma, Nico P.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974715/
https://ncbi.nlm.nih.gov/pubmed/31625269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13051
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