Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model

Murine leukemia virus (MLV) integrase (IN) lacking the C-terminal tail peptide (TP) loses its interaction with the host bromodomain and extraterminal (BET) proteins and displays decreased integration at promoter/enhancers and transcriptional start sites/CpG islands. MLV lacking the IN TP via an alte...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Loyola, Lorenz, Achuthan, Vasudevan, Gilroy, Kathryn, Borland, Gillian, Kilbey, Anna, Mackay, Nancy, Bell, Margaret, Hay, Jodie, Aiyer, Sriram, Fingerman, Dylan, Villanueva, Rodrigo A., Cameron, Ewan, Kozak, Christine A., Engelman, Alan N., Neil, James, Roth, Monica J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974304/
https://ncbi.nlm.nih.gov/pubmed/31815961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008154
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados