Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model

Murine leukemia virus (MLV) integrase (IN) lacking the C-terminal tail peptide (TP) loses its interaction with the host bromodomain and extraterminal (BET) proteins and displays decreased integration at promoter/enhancers and transcriptional start sites/CpG islands. MLV lacking the IN TP via an alte...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Loyola, Lorenz, Achuthan, Vasudevan, Gilroy, Kathryn, Borland, Gillian, Kilbey, Anna, Mackay, Nancy, Bell, Margaret, Hay, Jodie, Aiyer, Sriram, Fingerman, Dylan, Villanueva, Rodrigo A., Cameron, Ewan, Kozak, Christine A., Engelman, Alan N., Neil, James, Roth, Monica J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974304/
https://ncbi.nlm.nih.gov/pubmed/31815961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008154
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