DNA methylation analysis of multiple imprinted DMRs in Sotos syndrome reveals IGF2‐DMR0 as a DNA methylation‐dependent, P0 promoter‐specific enhancer

Haploinsufficiency of NSD1, which dimethylates histone H3 lysine 36 (H3K36), causes Sotos syndrome (SoS), an overgrowth syndrome. DNMT3A and DNMT3B recognizes H3K36 trimethylation (H3K36me3) through PWWP domain to exert de novo DNA methyltransferase activity and establish imprinted differentially me...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Watanabe, Hidetaka, Higashimoto, Ken, Miyake, Noriko, Morita, Sumiyo, Horii, Takuro, Kimura, Mika, Suzuki, Takayuki, Maeda, Toshiyuki, Hidaka, Hidenori, Aoki, Saori, Yatsuki, Hitomi, Okamoto, Nobuhiko, Uemura, Tetsuji, Hatada, Izuho, Matsumoto, Naomichi, Soejima, Hidenobu
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6973060/
https://ncbi.nlm.nih.gov/pubmed/31914674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201901757R
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