Growing oocyte-specific transcription-dependent de novo DNA methylation at the imprinted Zrsr1-DMR

BACKGROUND: Zrsr1 is a paternally expressed imprinted gene located in the first intron of Commd1, and the Zrsr1 promoter resides in a differentially methylated region (DMR) that is maternally methylated in the oocyte. However, a mechanism for the establishment of the methylation has remained obscure...

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Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: Joh, Keiichiro, Matsuhisa, Fumikazu, Kitajima, Shuji, Nishioka, Kenichi, Higashimoto, Ken, Yatsuki, Hitomi, Kono, Tomohiro, Koseki, Haruhiko, Soejima, Hidenobu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989421/
https://ncbi.nlm.nih.gov/pubmed/29875017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-018-0200-6
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