Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

Although fibroblast heterogeneity is recognized in primary tumors, both its characterization in and its impact on metastases remain unknown. Here, combining flow cytometry, immunohistochemistry and RNA-sequencing on breast cancer samples, we identify four Cancer-Associated Fibroblast (CAF) subpopula...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Pelon, Floriane, Bourachot, Brigitte, Kieffer, Yann, Magagna, Ilaria, Mermet-Meillon, Fanny, Bonnet, Isabelle, Costa, Ana, Givel, Anne-Marie, Attieh, Youmna, Barbazan, Jorge, Bonneau, Claire, Fuhrmann, Laetitia, Descroix, Stéphanie, Vignjevic, Danijela, Silberzan, Pascal, Parrini, Maria Carla, Vincent-Salomon, Anne, Mechta-Grigoriou, Fatima
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972713/
https://ncbi.nlm.nih.gov/pubmed/31964880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14134-w
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