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miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
High-grade serous ovarian cancers (HGSOC) have been subdivided into molecular subtypes. The mesenchymal HGSOC subgroup, defined by stromal-related gene signatures, is invariably associated with poor patient survival. We demonstrate that stroma exerts a key function in mesenchymal HGSOC. We highlight...
שמור ב:
| הוצא לאור ב: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group UK
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5849633/ https://ncbi.nlm.nih.gov/pubmed/29535360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03348-z |
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