Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients

Anti‐cancer drugs often increase reactive oxygen species (ROS) and cause DNA damage. Here, we highlight a new cross talk between chronic oxidative stress and the histone variant H2AX, a key player in DNA repair. We observe that persistent accumulation of ROS, due to a deficient JunD‐/Nrf2‐antioxidan...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:EMBO Mol Med
Autori principali: Gruosso, Tina, Mieulet, Virginie, Cardon, Melissa, Bourachot, Brigitte, Kieffer, Yann, Devun, Flavien, Dubois, Thierry, Dutreix, Marie, Vincent‐Salomon, Anne, Miller, Kyle Malcolm, Mechta‐Grigoriou, Fatima
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123617/
https://ncbi.nlm.nih.gov/pubmed/27006338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505891
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi