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Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients
Anti‐cancer drugs often increase reactive oxygen species (ROS) and cause DNA damage. Here, we highlight a new cross talk between chronic oxidative stress and the histone variant H2AX, a key player in DNA repair. We observe that persistent accumulation of ROS, due to a deficient JunD‐/Nrf2‐antioxidan...
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出版年: | EMBO Mol Med |
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主要な著者: | , , , , , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
John Wiley and Sons Inc.
2016
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5123617/ https://ncbi.nlm.nih.gov/pubmed/27006338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505891 |
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