PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers

High-grade serous ovarian cancer (HGSOC) remains an unmet medical challenge. Here, we unravel an unanticipated metabolic heterogeneity in HGSOC. By combining proteomic, metabolomic, and bioergenetic analyses, we identify two molecular subgroups, low- and high-OXPHOS. While low-OXPHOS exhibit a glyco...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Gentric, Géraldine, Kieffer, Yann, Mieulet, Virginie, Goundiam, Oumou, Bonneau, Claire, Nemati, Fariba, Hurbain, Ilse, Raposo, Graca, Popova, Tatiana, Stern, Marc-Henri, Lallemand-Breitenbach, Valérie, Müller, Sebastian, Cañeque, Tatiana, Rodriguez, Raphaël, Vincent-Salomon, Anne, de Thé, Hugues, Rossignol, Rodrigue, Mechta-Grigoriou, Fatima
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331342/
https://ncbi.nlm.nih.gov/pubmed/30244973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.09.002
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