Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

Although fibroblast heterogeneity is recognized in primary tumors, both its characterization in and its impact on metastases remain unknown. Here, combining flow cytometry, immunohistochemistry and RNA-sequencing on breast cancer samples, we identify four Cancer-Associated Fibroblast (CAF) subpopula...

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Udgivet i:Nat Commun
Main Authors: Pelon, Floriane, Bourachot, Brigitte, Kieffer, Yann, Magagna, Ilaria, Mermet-Meillon, Fanny, Bonnet, Isabelle, Costa, Ana, Givel, Anne-Marie, Attieh, Youmna, Barbazan, Jorge, Bonneau, Claire, Fuhrmann, Laetitia, Descroix, Stéphanie, Vignjevic, Danijela, Silberzan, Pascal, Parrini, Maria Carla, Vincent-Salomon, Anne, Mechta-Grigoriou, Fatima
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972713/
https://ncbi.nlm.nih.gov/pubmed/31964880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14134-w
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