Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice

Prekallikrein (PKK, also known as Fletcher factor and encoded by the gene KLKB1 in humans) is a component of the contact system. Activation of the contact system has been implicated in lethality in fulminant sepsis models. Pneumonia is the most frequent cause of sepsis. We sought to determine the ro...

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Bibliografiske detaljer
Udgivet i:J Pathol
Main Authors: Ding, Chao, Scicluna, Brendon P, Stroo, Ingrid, Yang, Jack, Roelofs, Joris JTH, de Boer, Onno J, de Vos, Alex F, Nürnberg, Peter, Revenko, Alexey S, Crosby, Jeff, van't Veer, Cornelis, van der Poll, Tom
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Ltd 2019
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Original Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972537/
https://ncbi.nlm.nih.gov/pubmed/31595971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5354
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