Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice

Prekallikrein (PKK, also known as Fletcher factor and encoded by the gene KLKB1 in humans) is a component of the contact system. Activation of the contact system has been implicated in lethality in fulminant sepsis models. Pneumonia is the most frequent cause of sepsis. We sought to determine the ro...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Ding, Chao, Scicluna, Brendon P, Stroo, Ingrid, Yang, Jack, Roelofs, Joris JTH, de Boer, Onno J, de Vos, Alex F, Nürnberg, Peter, Revenko, Alexey S, Crosby, Jeff, van't Veer, Cornelis, van der Poll, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2019
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972537/
https://ncbi.nlm.nih.gov/pubmed/31595971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5354
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