Tenascin-C Deficiency Is Associated With Reduced Bacterial Outgrowth During Klebsiella pneumoniae-Evoked Pneumosepsis in Mice

Tenascin C (TNC) is an extracellular matrix glycoprotein that recently emerged as an immunomodulator. TNC-deficient (TNC(−/−)) mice were reported to have a reduced inflammatory response upon systemic administration of lipopolysaccharide, the toxic component of gram-negative bacteria. Here, we invest...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Meijer, Mariska T., de Vos, Alex F., Scicluna, Brendon P., Roelofs, Joris J., Abou Fayçal, Chérine, Orend, Gertraud, Uhel, Fabrice, van der Poll, Tom
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2021
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990887/
https://ncbi.nlm.nih.gov/pubmed/33776992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.600979
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