WEE1 inhibition synergizes with CHOP chemotherapy and radiation therapy through induction of premature mitotic entry and DNA damage in diffuse large B-cell lymphoma

BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, characterized by high levels of genomic instability and the activation of DNA damage repair pathways. We previously found high expression of the cell cycle regulator WEE1 in DLBCL cell lines. Here, we investigated the comb...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Ther Adv Hematol
Egile Nagusiak: de Jong, Mathilde R. W., Langendonk, Myra, Reitsma, Bart, Herbers, Pien, Lodewijk, Monique, Nijland, Marcel, van den Berg, Anke, Ammatuna, Emanuele, Visser, Lydia, van Meerten, Tom
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: SAGE Publications 2020
Gaiak:
Original Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971956/
https://ncbi.nlm.nih.gov/pubmed/32010435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040620719898373
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