WEE1 inhibition synergizes with CHOP chemotherapy and radiation therapy through induction of premature mitotic entry and DNA damage in diffuse large B-cell lymphoma

BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, characterized by high levels of genomic instability and the activation of DNA damage repair pathways. We previously found high expression of the cell cycle regulator WEE1 in DLBCL cell lines. Here, we investigated the comb...

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Bibliografiske detaljer
Udgivet i:Ther Adv Hematol
Main Authors: de Jong, Mathilde R. W., Langendonk, Myra, Reitsma, Bart, Herbers, Pien, Lodewijk, Monique, Nijland, Marcel, van den Berg, Anke, Ammatuna, Emanuele, Visser, Lydia, van Meerten, Tom
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2020
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971956/
https://ncbi.nlm.nih.gov/pubmed/32010435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040620719898373
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