WEE1 inhibition synergizes with CHOP chemotherapy and radiation therapy through induction of premature mitotic entry and DNA damage in diffuse large B-cell lymphoma

BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, characterized by high levels of genomic instability and the activation of DNA damage repair pathways. We previously found high expression of the cell cycle regulator WEE1 in DLBCL cell lines. Here, we investigated the comb...

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Detalhes bibliográficos
Publicado no:Ther Adv Hematol
Main Authors: de Jong, Mathilde R. W., Langendonk, Myra, Reitsma, Bart, Herbers, Pien, Lodewijk, Monique, Nijland, Marcel, van den Berg, Anke, Ammatuna, Emanuele, Visser, Lydia, van Meerten, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971956/
https://ncbi.nlm.nih.gov/pubmed/32010435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040620719898373
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