WEE1 Inhibition Enhances Anti-Apoptotic Dependency as a Result of Premature Mitotic Entry and DNA Damage

Genomically unstable cancers are dependent on specific cell cycle checkpoints to maintain viability and prevent apoptosis. The cell cycle checkpoint protein WEE1 is highly expressed in genomically unstable cancers, including diffuse large B-cell lymphoma (DLBCL). Although WEE1 inhibition effectively...

Full description

Saved in:
Bibliographic Details
Published in:Cancers (Basel)
Main Authors: de Jong, Mathilde Rikje Willemijn, Langendonk, Myra, Reitsma, Bart, Herbers, Pien, Nijland, Marcel, Huls, Gerwin, van den Berg, Anke, Ammatuna, Emanuele, Visser, Lydia, van Meerten, Tom
Format: Artigo
Language:Inglês
Published: MDPI 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895818/
https://ncbi.nlm.nih.gov/pubmed/31703356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11111743
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items