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A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1

To enter into mitosis, cells must shut off the cell cycle inhibitor Wee1. SAD family protein kinases regulate Wee1 signaling in yeast and humans. In Schizosaccharomyces pombe, two SAD kinases (Cdr1/Nim1 and Cdr2) act as upstream inhibitors of Wee1. Previous studies found that S. pombe Cdr1/Nim1 dire...

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發表在:Mol Biol Cell
Main Authors: Opalko, Hannah E., Nasa, Isha, Kettenbach, Arminja N., Moseley, James B.
格式: Artigo
語言:Inglês
出版: The American Society for Cell Biology 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880885/
https://ncbi.nlm.nih.gov/pubmed/31644361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E19-08-0430
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