A rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9

BACKGROUND: Von Willebrand Disease (VWD) is the most common inherited bleeding disorder, caused by quantitative and qualitative changes in von Willebrand factor (VWF). The biology of VWD, studied in canine, porcine, and murine models, differ in species‐specific biology of VWF and the amenability to...

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Detalhes bibliográficos
Publicado no:Res Pract Thromb Haemost
Main Authors: Garcia, Jessica, Flood, Veronica H., Haberichter, Sandra L., Fahs, Scot A., Mattson, Jeremy G., Geurts, Aron M., Zogg, Mark, Weiler, Hartmut, Shi, Qizhen, Montgomery, Robert R.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles: Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971331/
https://ncbi.nlm.nih.gov/pubmed/31989086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12280
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