Protein phosphatase 2A activation as a therapeutic strategy for managing MYC-driven cancers

The tumor suppressor protein phosphatase 2A (PP2A) is a serine/threonine phosphatase whose activity is inhibited in most human cancers. One of the best-characterized PP2A substrates is MYC proto-oncogene basic helix–loop–helix transcription factor (MYC), whose overexpression is commonly associated w...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Farrington, Caroline C., Yuan, Eric, Mazhar, Sahar, Izadmehr, Sudeh, Hurst, Lauren, Allen-Petersen, Brittany L., Janghorban, Mahnaz, Chung, Eric, Wolczanski, Grace, Galsky, Matthew, Sears, Rosalie, Sangodkar, Jaya, Narla, Goutham
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6970930/
https://ncbi.nlm.nih.gov/pubmed/31822503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011443
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