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Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules

Insoluble, hyperubiquitylated TAR DNA-binding protein of 43 kDa (TDP-43) in the central nervous system characterizes frontotemporal dementia and ALS in many individuals with these neurodegenerative diseases. The causes for neuropathological TDP-43 aggregation are unknown, but it has been suggested t...

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書目詳細資料
發表在:J Biol Chem
Main Authors: Hans, Friederike, Glasebach, Hanna, Kahle, Philipp J.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6970928/
https://ncbi.nlm.nih.gov/pubmed/31780563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010617
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