Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules

Lignende værker

• Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43)
  af: Hans, Friederike, et al.
  Udgivet: (2018)
• Cytoplasmic TDP-43 de-mixing independent of stress granules drives inhibition of nuclear import, loss of nuclear TDP-43, and cell death
  af: Gasset-Rosa, Fatima, et al.
  Udgivet: (2019)
• Aggregation of the nucleic acid–binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation
  af: Chen, Youjun, et al.
  Udgivet: (2019)
• TDP-43 Aggregation In Neurodegeneration: Are Stress Granules The Key?
  af: Dewey, Colleen M., et al.
  Udgivet: (2012)
• Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice
  af: Beel, Sander, et al.
  Udgivet: (2018)