PASylation of IL-1 receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis

Interleukin-1 (IL-1) is a key mediator of inflammation and immunity. Naturally-occurring IL-1 receptor antagonist (IL-1Ra) binds and blocks the IL-1 receptor-1 (IL-1R1), preventing signaling. Anakinra, a recombinant form of IL-1Ra, is used to treat a spectrum of inflammatory diseases. However, anaki...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Powers, Nicholas E., Swartzwelter, Benjamin, Marchetti, Carlo, de Graaf, Dennis M., Lerchner, Alexandra, Schlapschy, Martin, Datar, Rajiv, Binder, Uli, Edwards, Carl K., Skerra, Arne, Dinarello, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6970921/
https://ncbi.nlm.nih.gov/pubmed/31819009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010340
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