High contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation

Although antigen-binding fragments (Fabs) of antibodies constitute established tracers for in vivo radiodiagnostics, their functionality is hampered by a very short circulation half-life. PASylation, the genetic fusion with a long, conformationally disordered amino acid chain comprising Pro, Ala and...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Mendler, Claudia T, Friedrich, Lars, Laitinen, Iina, Schlapschy, Martin, Schwaiger, Markus, Wester, Hans-Jürgen, Skerra, Arne
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622060/
https://ncbi.nlm.nih.gov/pubmed/25484039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19420862.2014.985522
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