Accelerated neuronal and synaptic maturation by BrainPhys medium increases Aβ secretion and alters Aβ peptide ratios from iPSC-derived cortical neurons

One of the neuropathological hallmarks of Alzheimer’s disease (AD) is cerebral deposition of amyloid plaques composed of amyloid β (Aβ) peptides and the cerebrospinal fluid concentrations of those peptides are used as a biomarker for AD. Mature induced pluripotent stem cell (iPSC)-derived cortical n...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Satir, Tugce Munise, Nazir, Faisal Hayat, Vizlin-Hodzic, Dzeneta, Hardselius, Erik, Blennow, Kaj, Wray, Selina, Zetterberg, Henrik, Agholme, Lotta, Bergström, Petra
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969066/
https://ncbi.nlm.nih.gov/pubmed/31953468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57516-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items