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Accelerated neuronal and synaptic maturation by BrainPhys medium increases Aβ secretion and alters Aβ peptide ratios from iPSC-derived cortical neurons

One of the neuropathological hallmarks of Alzheimer’s disease (AD) is cerebral deposition of amyloid plaques composed of amyloid β (Aβ) peptides and the cerebrospinal fluid concentrations of those peptides are used as a biomarker for AD. Mature induced pluripotent stem cell (iPSC)-derived cortical n...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Rep
मुख्य लेखकों: Satir, Tugce Munise, Nazir, Faisal Hayat, Vizlin-Hodzic, Dzeneta, Hardselius, Erik, Blennow, Kaj, Wray, Selina, Zetterberg, Henrik, Agholme, Lotta, Bergström, Petra
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2020
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969066/
https://ncbi.nlm.nih.gov/pubmed/31953468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57516-7
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