HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms

Protein acetylation is an important contributor to cancer initiation. Histone deacetylase 6 (HDAC6) controls JAK2 translation and protein stability and has been implicated in JAK2-driven diseases best exemplified by myeloproliferative neoplasms (MPNs). By using novel classes of highly selective HDAC...

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書誌詳細
出版年:Blood
主要な著者: Yue, Lanzhu, Sharma, Vasundhara, Horvat, Nathan P., Akuffo, Afua A., Beatty, Matthew S., Murdun, Cem, Colin, Christelle, Billington, Julia M. R., Goodheart, William E., Sahakian, Eva, Zhang, Ling, Powers, John J., Amin, Narmin E., Lambert-Showers, Que T., Darville, Lancia N., Pinilla-Ibarz, Javier, Reuther, Gary W., Wright, Kenneth L., Conti, Chiara, Lee, Jennifer Y., Zheng, Xiaozhang, Ng, Pui Yee, Martin, Matthew W., Marshall, C. Gary, Koomen, John M., Levine, Ross L., Verma, Amit, Grimes, H. Leighton, Sotomayor, Eduardo M., Shao, Zonghong, Epling-Burnette, Pearlie K.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2020
主題:
Myeloid Neoplasia
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966930/
https://ncbi.nlm.nih.gov/pubmed/31750881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019895326
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